A Deep Dive Into Lactobacilli

If you’ve ever had BV, thrush, or both in a frustrating cycle, you’re not alone. Vaginal infections are common and they’re rarely about hygiene or bad luck. The real story lies much deeper, in the balance of your vaginal microbiome. At the heart of it all: Lactobacilli – the protective bacteria working to keep things stable. In this article, we explore what lactobacilli actually do, what disrupts them, and how you can support them, so they can protect your vaginal health. 

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A Deep Dive Into Lactobacilli

If you’ve ever had BV, thrush, or both in a frustrating cycle, you’re not alone. Vaginal infections are common and they’re rarely about hygiene or bad luck. The real story lies much deeper, in the balance of your vaginal microbiome. At the heart of it all: Lactobacilli – the protective bacteria working to keep things stable. In this article, we explore what lactobacilli actually do, what disrupts them, and how you can support them, so they can protect your vaginal health. 

What are Lactobacilli – and why do they matter? 

Lactobacilli are the natural protectors of your vaginal microbiome. They’re often described as the “good bacteria”, which doesn’t quite do them justice. Lactobacilli actively work behind the scenes to keep infections in check and your vaginal health on track. 

Here’s what they do:

  • Lower the pH
    Lactobacilli produce lactic acid, which keeps your vaginal pH slightly acidic (around 3.8–4.5). This acidity helps stop harmful bacteria and yeast from growing out of control.

  • Control the resources
    Lactobacilli dominate, using up nutrients and space and making it difficult for unwanted bacteria to survive or take hold.

  • Fight infection directly
    Some strains of lactobacilli produce antimicrobial compounds like hydrogen peroxide and bacteriocins, which actively kill or weaken other microbes before they can cause problems.

  • Build a barrier
    Lactobacilli stick to the vaginal walls, forming a natural shield that helps stop bacteria from latching on.

  • Support your immune system
    They help your body recognise real threats without triggering unnecessary inflammation, which keeps you symptom-free.

When lactobacilli are thriving, your vaginal microbiome stays more resilient – even when life throws in the usual disruptors like hormones, sex or antibiotics. 


What does a healthy vaginal microbiome look like?

Vaginal microbiomes aren’t one-size-fits-all, they’re unique – but in general, a healthy one is:

  • Dominated by one or more species of lactobacilli
  • Low in microbial diversity (unlike the gut, where more diversity is better)
  • Stable over time, even through common changes like periods or sex

Researchers have begun to group vaginal microbiomes into different “community state types” (CSTs), also known as vaginotypes:

  • Types 1, 2, 3, and 5: Dominated by lactobacilli, showing a generally healthy environment.

  • Type 4: More diverse, with fewer or no lactobacilli and more bacteria linked to infections like BV.  

It’s worth noting that not everyone has a lactobacillus-dominant microbiome. Type 4 is more common in Black and Hispanic women, even without symptoms. That doesn’t make them unhealthy, it’s just a reminder that vaginal health looks different for everyone.


What causes Lactobacilli levels to drop?

Your vaginal microbiome is sensitive. Even when you’re feeling fine, small changes can quietly shift the balance. Knowing what affects your microbiome is an important step towards understanding your body and feeling more in control. 

Some of the most common disruptors include:  

  • Your period: Menstrual blood raises vaginal pH, making it harder for protective lactobacilli to thrive.

  • Sex: Semen is alkaline and raises vaginal pH. Unprotected sex (especially with new partners) can also introduce unfamiliar microbes.

  • Antibiotics: These don’t just target infection; they wipe out good bacteria too, creating space for infection to develop.

  • Hormonal changes: Oestrogen influences glycogen production (the food source for lactobacilli). Drops in oestrogen (post-birth, during menopause, or with some contraceptives) can lower lactobacilli levels.

  • Lifestyle factors: Smoking, poor diet, high stress levels and vaginal washing (especially douching) are all linked to lower lactobacilli levels.

It’s rarely just one trigger. Often, symptoms appear after a combination of factors, like taking antibiotics right before your period, or starting a new contraceptive method when your body is already run down. 


What happens when Lactobacilli are lost?

When lactobacilli levels drop, your defences weaken. This allows harmful microbes to take over, a state known as dysbiosis

Common signs include:  

  • Bacterial vaginosis (BV): Often causes discharge and a fishy odour, but not always. It's strongly linked to low lactobacilli and an overgrowth of other bacteria like Gardnerella and Prevotella.

  • Thrush (Vulvovaginal Candidiasis): Caused by an overgrowth of natural yeast called Candida. Thrush is more likely when your microbiome is disrupted, especially after taking antibiotics or hormonal shifts.

  • The BV-Thrush cycle: Many women find themselves stuck in a loop, treating BV with antibiotics, only for thrush to be triggered by the treatment. 

The impact of dysbiosis can go beyond everyday symptoms. Research shows that a low-lactobacilli vaginal microbiome may also increase the risk of:

  • STIs (including chlamydia, gonorrhoea, HPV, HIV, and herpes). 
  • Fertility issues, including lower IVF success rates. 
  • Pregnancy complications, like preterm birth and low birth weight.

This is why restoring and protecting your microbiome matters – not just to treat symptoms, but to protect your wider, long-term health.


Can I restore my Lactobacilli?

Yes. And it can be a crucial step toward breaking the cycle of repeat infections. The best approach depends on your symptoms, health history, and what triggered the disruption in the first place. While there’s no single fix, science is starting to uncover what really helps lactobacilli thrive again. 


What research suggests may help:

  • Probiotics
    Specific strains of lactobacilli can help restore balance and reduce the risk of BV and thrush coming back. Vaginal suppositories tend to work faster than oral tablets.

  • Lifestyle Changes
    A high-fibre, plant-based diet and regular exercise have been linked to more stable, lactobacillus-dominant microbiomes.

  • Hormonal Support
    If oestrogen levels are low, hormone-based therapies (like HRT or certain contraceptives) may help restore lactobacilli levels.

  • Avoiding Triggers
    Reduce unnecessary antibiotic use, avoid perfumed soaps or douching, and use condoms during sex to help keep your microbiome more stable.


The Bottom Line 

Your vaginal microbiome is constantly changing and adapting, shaped by hormones, health choices and everyday life. Lactobacilli are at the heart of it all, quietly doing the work to keep things balanced. 

We know just how common repeat vaginal infections are – and how often the usual treatments fail to address the root cause, leaving women confused about what’s happening in their own bodies. 

Restoring balance isn’t a quick fix. It’s about choosing treatments and habits that protect your microbiome, not disrupt it. That’s why at UVISA, we’re focused on solutions that support your body’s natural defences, so lactobacilli can keep doing what they do best. 


Sources

  1. The Vaginal Microenvironment: The Physiologic Role of Lactobacilli
  2. Vaginotypes of the human vaginal microbiome
  3. The association between lifestyle factors and the composition of the vaginal microbiota: a review
  4. Towards a deeper understanding of the vaginal microbiota
  5. The Vaginal Microbiome: I. Research Development, Lexicon, Defining “Normal” and the Dynamics Throughout Women's Lives
  6. Daily Vaginal Microbiota Fluctuations Associated with Natural Hormonal Cycle, Contraceptives, Diet, and Exercise
  7. Vaginal microbiome: normalcy vs dysbiosis
  8. Protective Mechanisms of Vaginal Lactobacilli against Sexually Transmitted Viral Infections
  9. Healthy Vaginal Microbiota and Influence of Probiotics Across the Female Life Span
  10. The impact of contraceptives on the vaginal microbiome